Acetaminophen and Codeine Phosphate 300mg For Sale
Acetaminophen and Codeine Phosphate 300mg
Acetaminophen and codeine phosphate tablets expose patients and other users to the risks of opioid addiction, abuse and misuse, which can lead to overdose and death. Assess each patient’s risk prior to prescribing acetaminophen and codeine phosphate tablets, and monitor all patients regularly for the development of these behaviors and conditions
Serious, life-threatening, or fatal respiratory depression may occur with use of acetaminophen and codeine phosphate tablets. Monitor for respiratory depression, especially during initiation of acetaminophen and codeine phosphate tablets or following a dose increase
Accidental ingestion of acetaminophen and codeine phosphate tablets, especially by children, can result in a fatal overdose of acetaminophen and codeine phosphate tablets
Ultra-Rapid Metabolism of Codeine and Other Risk Factors for Life-Threatening Respiratory Depression in Children
Life-threatening respiratory depression and death have occurred in children who received codeine. Most of the reported cases occurred following tonsillectomy and/or adenoidectomy and many of the children had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism. Acetaminophen and codeine phosphate tablets are contraindicated in children younger than 12 years of age and in children younger than 18 years of age following tonsillectomy and/or adenoidectomy. Avoid the use of acetaminophen and codeine phosphate tablets in adolescents 12 to 18 years of age who have other risk factors that may increase their sensitivity to the respiratory depressant effects of codeine.
Acetaminophen may interact with a variety of other medicines. When this happens, the effects of one or both of the drugs may change or the risk of side effects may be greater. Among the drugs that may interact with acetaminophen are the following:
- nonsteroidal anti-inflammatory drugs (NSAIDs) such as Motrin
- oral contraceptives
- the antiseizure drug phenytoin (Dilantin)
- the blood-thinning drug warfarin (Coumadin)
- the cholesterol-lowering drug cholestyramine (Questran)
- the antibiotic Isoniazid
- zidovudine (Retrovir, AZT)
Check with a physician or pharmacist before combining acetaminophen with any other prescription or nonprescription (over-the-counter) medicine.
Acetaminophen is generally safe when taken as directed. Acetaminophen is commonly mixed with other ingredients as part of combinations intended for colds, influenza, and other conditions. Parents should read the labels carefully in order to avoid giving an overdose of acetaminophen to their child. They need to be particularly cautious about liquid medicines that contain acetaminophen and alcohol.